Computer Modeling Points to New Drug Target for PKD

Researchers from Indiana University have made important discoveries about PKD cyst formation using virtual tissue technology. Building a virtual nephron, the scientists used computer simulation to show that PKD gene mutations caused errors in cell adhesion. When cells failed to stick together, they formed mushroom-shaped cysts. When cells stuck together,…

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Reducing Calories Helps Mice with PKD

Mayo Clinic researchers have discovered that reducing calories in mice with PKD can prevent, improve, and reverse the disease. They saw a decrease in kidney inflammation, cell injury, and fibrosis. Restricting calories by 40% produced the most dramatic results, “almost completely” preventing and reversing CKD, but even a 10% reduction…

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New PKD Treatment Targets Kidney Blood Vessels

Researchers from the University of Manchester and University College London believe targeting the small blood vessels surrounding renal cysts could lead to a new treatment for polycystic kidney disease. They uncovered important abnormalities in the network of these blood vessels in mouse models of the most common form of PKD…

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Top News for PKD Research

Researchers continue to make important and sometimes surprising discoveries about PKD and the PKD1 gene. Here is a roundup of the latest PKD findings. A University of Colorado School of Medicine study has shown that pravastatin can slow down the growth of PKD cysts in children and young adults. –…

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Citrus Fruit Compound Naringenin Could Prevent PKD Cysts

A team of scientists in England has found that naringenin, an antioxidant and anti-inflammatory compound in grapefruit, oranges and tomatoes, could be the basis for a promising new treatment for polycystic kidney disease (PKD). Using a single-celled amoeba, they found that naringenin inhibits PKD cysts by regulating levels of the…

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Surprising Mechanism Discovered in PKD

Researchers from Yale University School of Medicine have discovered a new mechanism that affects both the severity and progression of PKD. Previously, cyst growth has been linked to mutations in the PKD1 and PKD2 genes and their associated proteins, polycystin-1 and -2. Scientists have found that defective cilia in renal…

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