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Posts Tagged ‘research’

Tuesday, April 3rd, 2012

We are excited to announce that Dr. Janos Peti-Peterdi is receiving recognition from leading scientific societies and the renal research community for his UKRO-funded work on urinary succinate and the metabolic receptor GPR91. He will be an invited speaker this November at the American Society of Nephrology meeting in San Diego, giving a symposium talk on his translational studies of urinary succinate/GPR91 and the role they play in renovascular hypertension. We are thrilled that he will be acknowledging UKRO’s support in front of such a large and prestigious audience.

Dr. Peti-Peterdi’s colleagues on this project have great news to share as well. Nikhil Kamat has been awarded an American Society of Nephrology Student Scholar Fellowship. Anne Riquier-Brison, a postdoctoral fellow and recipient of UKRO’s 2010 John McKay Fellowship in Renal Research, has submitted an abstract to the Experimental Biology Meeting in San Diego. Her work was selected for an oral presentation in a symposium sponsored by the American Physiological Society Renal Section. Anne will be giving her talk on April 23, 2012, and was also asked to be chair of her session. In praising his fellow researchers, Peti-Peterdi said, “These are wonderful achievements for Anne and Nikhil, and in recognition of our work. We are very proud to be sponsored by UKRO on this exciting project!”

 

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Monday, March 7th, 2011

By now you have probably heard of the national proposal to change the way kidneys are allocated – bypassing the traditional transplant waiting list and matching kidneys by age rather than length of time spent on the list. The topic has sparked heated debate in the kidney community and beyond. Our founder, Ken Kleinberg, recently wrote a letter in response to an editorial on kidney rationing in the New York Times. Here is the original editorial followed by Ken’s letter.

Editorial in the New York Times, Transplants and Rationing

Published: February 27, 2011

The number of kidneys available for transplants falls far short of the need, so there is no choice but to ration them. An emotionally difficult proposal to change the first-come-first-served transplant system makes good sense.

There are nearly 90,000 people on waiting lists to receive kidney transplants, and in 2009 there were only some 10,400 kidneys from dead donors to give them. And about 6,300 kidneys were transplanted from living people who donated one of their two kidneys and usually specified the recipient.

Currently the kidneys from dead donors are provided, through an organ procurement and transplantation network, to people who have been waiting the longest. That may seem fair since many transplant candidates wait for years, and some die while waiting.

But the system has serious shortcomings. Some elderly recipients get kidneys that could function far longer than they will live and that could have done more good for a younger recipient. Some younger recipients get kidneys that will fail and will need to be replaced, using up another scarce kidney.

These problems could be eased through a proposal under consideration at the transplant network to better match the likely longevity of the patient with the likely functional life of the kidney.

The patients and kidneys would each be graded separately. About 20 percent of the kidneys predicted to have the longest functional lives would be provided to the youngest and healthiest patients. The other 80 percent of kidneys would go to patients who are no more than 15 years older or younger than the donor.

The approach seems likely to make it harder for elderly people to get a kidney. But when kidneys are already scarce — and apt to get scarcer as much of the population ages and sickens — it is a rational choice.

UKRO Founder’s Response

March 4, 2011

A discussion on how best to distribute the limited number of kidneys available for transplantation is appropriate, but this will not resolve the problem. Quite simply, too many people have kidney disease—nearly 30 million in the United States alone—and millions more are at risk. Only research can hasten the discovery of more effective treatments for kidney-related diseases, and in the process diminish the growing need for transplants.

The enormity of human and economic losses from kidney disease cannot be over­stated. Nonetheless, kidney disease research remains a low priority nationally and is chronically under-funded. Bringing kidney research to the top of the public mind—like AIDS, cancer, heart disease, etc.—can help make vital funding a national imperative.

Kenneth Kleinberg, President, UKRO

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Thursday, February 10th, 2011

Here are two top kidney research breakthroughs that would compliment dialysis and one, involving a study of zebra fish, which could eliminate the need for dialysis and transplantation altogether!

The biological artificial kidneys described in this Medical Minute audio segment wouldn’t eliminate dialysis altogether, but they have fascinating potential. – Investigators Developing Biological Artificial Kidneys

This breakthrough would provide new hope for dialysis patients with unhealthy veins. – Bioengineered Veins Could Be Used for Dialysis

Zebra fish may show us how to regenerate diseased human kidneys. – Adult Stem Cells Found in Fish

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Friday, December 17th, 2010

This was an exciting week for kidney research and therapy breakthroughs! Here are the top 4.

Novel Virus-Based Gene Therapy for Metastatic Kidney Cancer Developed at Virginia Commonwealth University Massey Cancer Center

Blood Test for Cystatin C Can Predict Complications of Kidney Disease

National Kidney Foundation Study Reveals that Lupus is More Lethal Form of Kidney Disease in Children

University of Illinois Medical Center at Chicago Surgeons Offer Obese Kidney Patients New Hope with Robotic Transplantation

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Tuesday, April 20th, 2010

From BBC News
April 12, 2010
An international team of researchers has identified 20 genes related to kidney function and the production and secretion of creatinine that could explain more about the causes and biology of chronic kidney disease. This is a great breakthrough, but there is still more research to do!
Scientists Hail Revolutionary Kidney Gene Find

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Sunday, March 28th, 2010

From Medical News Today
March 5, 2010
According to a new study, the plant extract Pycnogenol, which comes from the bark of a French pine tree, fights kidney damage caused by high blood pressure and improves blood flow to the kidneys. After taking Pycnogenol in combination with the blood pressure medication Rampiril, hypertensive patients with early signs of kidney damage had less protein in their urine and lower blood pressure.
Pycnogenol Lowers Elevated Urinary Protein Levels and Improves Blood Flow to the Kidneys

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Friday, March 5th, 2010

From The Jerusalem Post
February 12, 2010
Israeli researchers have uncovered new genetic data to help explain the high rates of kidney disease among people of African descent.
Haifa Scientists’ Find May Help Millions

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Tuesday, February 2nd, 2010

From Healing Well
February 2, 2010
Researchers recommend tests to assess protein levels in the urine as well as standard serum creatinine tests to more accurately predict kidney function and risk of clinical outcomes including kidney failure and death.
Protein Levels in Urine Help Predict Kidney Function

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Friday, November 6th, 2009

From Medical News Today
November 2, 2009
In an 11 year study of 3000 women, researchers link diets high in sodium and soda to a decline in kidney function.
Study Shows Diets High In Sodium And Artificially Sweetened Soda Linked To Kidney Function Decline

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Tuesday, October 20th, 2009

From Los Angeles Times
January 29, 2009

A long-term study from University of Minnesota Medical School finds that kidney donors have normal life spans and fewer kidney problems than the general population, possibly because of careful health screening prior to donation.
Kidney Donors Have a Normal Life Span, Study Finds

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