Researchers at the University of Louisville have used a mouse model to show how human kidney genes change as diabetic nephropathy progresses. By studying gene expression, they discovered that inflammatory genes underwent the most changes. Paul Epstein, Ph.D., acting director of the Kosair Children’s Hospital Research Institute said, “In future studies, we can use this mouse model to explore whether inflammation causes disease progression or if the progression of the disease causes further inflammation. If it turns out that inflammation is causal, the next step would be to test the effectiveness of anti-inflammatory drugs.”

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UofL Researchers Replicate Human Kidney Gene Changes in Mouse Model, University of Louisville, May 23, 2011

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