Researchers from the University of Freiberg in Germany have identified a metabolic enzyme called mTOR as a target for preventing diabetic kidney disease. They showed that while mTOR is important to early glomerular development, it becomes overactive in diabetics, causing damage to the filtering units of the kidney. Using a mouse model, the scientists inhibited mTOR activation genetically to stop the progression of kidney damage. The discovery may one day result in a viable therapy for diabetic nephropathy and other glomerular diseases.
When Sugar Damages Kidneys: New Hope for Diabetes Patients with Kidney Disease, University of Freiberg, June 15, 2011