The renin-angiotensin system or RAS regulates blood pressure and fluid balance in the body. When blood volume or sodium levels in the body are low, or blood potassium is high, cells in the kidney release the enzyme, renin. Renin converts angiotensinogen, which is produced in the liver, to the hormone angiotensin I. An enzyme known … Continue reading The Renin-Angiotensin System and Blood Pressure Control
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Janos’s Story
I consider myself a very fortunate person. During my life so far, I have received many of God’s blessings: parents who gave me important guidance, principles, and determination; congenial professors and people who provided me with the right models, knowledge, and wisdom; and a wonderful, loving, and supportive family. For some people, it is quite … Continue reading Janos’s Story
Absence of Intrarenal ACE Protects Against Hypertension
A team of researchers, including Dr. Janos Peti-Peterdi and Dr. Alicia McDonough of the Keck School of Medicine of USC, has identified a new target for eliminating hypertension, which is a leading cause of kidney disease. The initial research was funded in part by a grant from UKRO. The renin-angiotensin system or RAS regulates blood … Continue reading Absence of Intrarenal ACE Protects Against Hypertension
Amniotic Fluid Stem Cells Slow Kidney Disease Progression
Scientists at the Saban Research Institute at The Children’s Hospital Los Angeles have shown that stem cells from amniotic fluid can slow kidney disease progression in mice with Alport syndrome. Treating the mice with stem cells prior to the onset of proteinuria improved survival rates, delayed the progression of kidney scarring and lessened the decline … Continue reading Amniotic Fluid Stem Cells Slow Kidney Disease Progression
Janos Peti-Peterdi: Succinate and GPR91 Play Role in Renovascular Hypertension
In 2012, Dr. Janos Peti-Peterdi continued to explore urinary succinate and the metabolic receptor GPR91 in a UKRO-funded project. The broad, long-term objective of his work is to establish the importance of succinate/GPR91 signaling and the role of the distal nephron in the pathomechanism of kidney disease and renovascular hypertension (RVHT). He theorizes that, in … Continue reading Janos Peti-Peterdi: Succinate and GPR91 Play Role in Renovascular Hypertension
Janos Peti-Peterdi: Succinate and GPR91 Play Role in Diabetic Kidney Disease
A UKRO seed grant supported the Peti-Peterdi lab at the University of Southern California in performing translational studies on diabetic kidney disease, which is the number-one cause of chronic kidney disease and kidney failure. The investigator team, led by Dr. Janos Peti-Peterdi, discovered a new sensing and controlling mechanism of cell and tissue metabolism (a … Continue reading Janos Peti-Peterdi: Succinate and GPR91 Play Role in Diabetic Kidney Disease