Researchers at the Translational Genomics Research Institute (TGen) in Phoenix, Arizona are shedding new light on the role of the PVT1 gene in reducing kidney filtration and causing diabetic kidney disease. They discovered that high blood sugar increases the rate of PVT1 gene expression, unleashing proteins associated with damage to the mesangial cells of the glomerulus. Using RNA interference, they were able to curb the gene’s expression and reduce protein production.
Source:
TGen Findings Contribute to Understanding of Diabetic Kidney Disease, The Translational Genomics Research Institute, April 22, 2011