Researchers at Stanford University School of Medicine have identified a drug called STF-31 that starves and kills some kidney cancer cells by cutting off their energy supply of glucose. STF-31 works by binding to a particular glucose transporter. Testing in mice inhibited glucose transport by about half and resulted in slowed tumor growth with limited … Continue reading Potential Kidney Cancer Therapy Starves Cancer Cells of Glucose
Researchers Discover Cause of FSGS
A team of nephrologists and researchers at University of Miami Miller School of Medicine have discovered a factor in the blood that may be responsible for up to two-thirds of the cases of focal segmental glomerulosclerosis or FSGS. They found that an excess of serum soluble urokinase receptor (suPAR) activates a protein in the kidney … Continue reading Researchers Discover Cause of FSGS
Rac1 Gene Implicated in Salt-Induced High Blood Pressure
Researchers at University of Tokyo Graduate School of Medicine have uncovered a new mechanism behind salt-sensitive hypertension. They found that a high-salt diet fed to salt-sensitive rats activates a gene called Rac1 in the kidneys; this leads to increased activity of the MR (Mineralocorticoid Receptor) protein and causes elevated blood pressure and kidney damage. Their … Continue reading Rac1 Gene Implicated in Salt-Induced High Blood Pressure
Src Gene May Be Key to Helping Kidney Cancer Patients
Researchers from Oregon Health and Science University Knight Cancer Institute have found that a gene called Src plays a role in helping some kidney cancers grow. The researchers are now looking at existing, approved drugs that may inhibit Src activity in cancer cells. In addition, they have developed a method of identifying patients that could … Continue reading Src Gene May Be Key to Helping Kidney Cancer Patients
UKRO’s Ron Taubman Appointed to OPTN/UNOS Kidney Committee
On July 1, 2011, Ronald S. Taubman, Board Member and Chair of UKRO’s Development Committee was appointed to a two-year term on the OPTN/UNOS Kidney Committee. Ron has been involved in local, state, and national organ and tissue donation and transplant issues for the last 10 years. He previously served as the Region 5 Representative … Continue reading UKRO’s Ron Taubman Appointed to OPTN/UNOS Kidney Committee
Older Living Kidney Donors in the News
Recent stories about older living kidney donors, including some with medical issues, are truly inspiring and encouraging given the organ shortage. In an interesting article, Stephen Textor, M.D., Professor of Medicine at Mayo Clinic, describes his experience with donors with moderate essential hypertension, who would normally be excluded from donating. – Medical Abnormalities Need Not … Continue reading Older Living Kidney Donors in the News