Researchers from Perelman School of Medicine at University of Pennyslvania have found a way to temporarily suppress the damaging inflammatory response brought on by dialysis. In earlier studies, the research team showed that polymer-based dialysis filters activate the body’s complement system, a part of the immune system made up of circulating proteins that help antibodies destroy foreign molecules. The scientists were able to suppress the complement system in primates using a compound called Cp40, a variation of the drug, compstatin. They believe a similar, short-term treatment administered only during dialysis could help kidney patients avoid the complications of inflammation, which include cardiovascular disease and anemia.
Taming the Inflammatory Response in Kidney Dialysis, ScienceDaily, December 12, 2014